Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle
نویسندگان
چکیده
منابع مشابه
Bystander communication and cell cycle decisions after DNA damage
The DNA damage response (DDR) has two main goals, to repair the damaged DNA and to communicate the presence of damaged DNA. This communication allows the adaptation of cellular behavior to minimize the risk associated with DNA damage. In particular, cell cycle progression must be adapted after a DNA-damaging insult, and cells either pause or terminally exit the cell cycle during a DDR. As cells...
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Although it is well established that plant seeds treated with high doses of gamma radiation arrest development as seedlings, the cause of this arrest is unknown. The uvh1 mutant of Arabidopsis is defective in a homolog of the human repair endonuclease XPF, and uvh1 mutants are sensitive to both the toxic effects of UV and the cytostatic effects of gamma radiation. Here we find that gamma irradi...
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BACKGROUND Components of the DNA damage checkpoint are essential for surviving exposure to DNA damaging agents. Checkpoint activation leads to cell cycle arrest, DNA repair, and apoptosis in eukaryotes. Cell cycle regulation and DNA repair appear essential for unicellular systems to survive DNA damage. The relative importance of these responses and apoptosis for surviving DNA damage in multicel...
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Human genetic disorders present a logical starting point for the identification and functional analysis of numerous proteins. In addition to understanding a disease and searching for a cure, the identification of a “culprit” gene and the corresponding protein may shed light on fundamental biological processes. The human autosomal recessive disorder ataxia-telangiectasia (A-T) is a prime example...
متن کاملATM to the rescue: repairing DNA damage.
Human genetic disorders present a logical starting point for the identification and functional analysis of numerous proteins. In addition to understanding a disease and searching for a cure, the identification of a “culprit” gene and the corresponding protein may shed light on fundamental biological processes. The human autosomal recessive disorder ataxia-telangiectasia (A-T) is a prime example...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2019
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201811100